Building bones and testing their properties

Michelle and Tammy provided mechanical expertise, in the form of nanoindentation testing and analysis, for a collaboration with the group of Molly Stevens at Imperial College London, Dept. of Materials. The study examined, using a wide variety of characterization techniques, the bone-like material formed by embryonic stem cells, adult stem cells and differentiated osteoblast cells. Interestingly, the material created by the embryonic stem cells was least “bone-like” while the tissue produced by the adult cells was both bone-like and similar to the osteoblast-derived tissue. Mechanically, there was about an order of magnitude difference between the tissue types, with embryonic cell-derived tissue demonstrating significantly smaller stiffness values compared with the other two groups. A write-up of the study appears in Nature Reports Stem Cells and the paper appeared recently in Nature Materials.

Comments are closed.