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This summer, Suhda Anilkumar, an undergraduate from the University of Delaware, joined the Washington University team as a National Science Foundation (NSF) Research Experience for Undergraduates (REU) intern. Participating in the Summer Program for Engineering Research towards a Virtual Pregnancy, Suhda gained valuable experience and insights into the cutting-edge research conducted at the university …

Samantha Zambuto recently attended the Gordon Research Seminar (GRS) on Signal Transduction by Engineered Extracellular Matrices, where she presented her research on “Biomimetic Matrices for Modeling Uteroplacental Interfacing.” The seminar, which took place in a dynamic forum for young doctoral and post-doctoral researchers, focused on exploring engineered microenvironments to study tissue heterogeneity and address underserved diseases and populations in biomedical research. Samantha’s poster highlighted innovative approaches for designing tissue-engineered constructs to reduce complications in pregnancy. This GRS meeting provided a platform for early-career scientists to engage in scientific discussions, develop collaborative relationships, and explore diverse career opportunities in academia, industry, and publishing …

Dr. Adrienne Scott and Samyuktha Kolluru represented Oyen Lab in Washington University in St. Louis at the Wellcome In Utero Hackathon held in the United Kingdom from June 18-21, 2024. The hackathon showcased innovative techniques in the analysis of the placenta and maternal health …

Adrienne Scott and Samyuktha Kolluru from Washington University recently attended the Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C2024), held from June 11–14, 2024, at the Grand Geneva Resort in Lake Geneva, Wisconsin. The conference, themed “Innovation without Borders: Uniting Ideas, Technologies, and Communities,” featured a range of plenary lectures, symposia, and workshops. The event focused on biotransport, device design, rehabilitation, bioengineering education, fluid mechanics, tissue engineering, and solid mechanics. The SB3C2024 provided a platform for scientific dissemination, diversity/mentoring, and student-centered activities, fostering valuable discussions and connections among peers …

Dr. Michelle Oyen and PhD candidate Samyuktha Kolluru from Washington University played key roles at the NSF-funded Engineering Research Visioning Alliance (ERVA) event, “Transforming Women’s Health Outcomes through Engineering.” Dr. Oyen, serving as chair, and Kolluru, as her scribe, collaborated with co-chair Kristin Myers to unite stakeholders nationwide. The event focused on leveraging engineering innovations to address critical women’s health issues, emphasizing interdisciplinary collaboration to drive advancements in maternal, fetal, and gynecologic health. Their efforts highlight the significant impact of engineering on women’s healthcare outcomes …

World Biomaterials Congress’s BuildingDr. Samantha Zambuto standing next day’s schedule.Dr. Samantha Zambuto (Left) and Dr. Juan Gnecco (right)Dr. Samantha Zambuto (Left) and Eya Ferchichi exploring Korea Date: July 5, 2024St Louis, MO – We’re thrilled to report that Samantha Zambuto had a highly successful trip to the World Biomaterials Congress in Korea. Her insightful talk on “Biomaterials for Maternal-Fetal Interface,” held on May 28, 2024, captivated the audience. Zambuto’s presentation provided valuable insights into the use of biomaterials to improve maternal and fetal health, contributing to meaningful discussions among attendees …

Date: May 24, 2024 St. Louis, MO – We’re excited to announce that Dr. Samantha Zambuto will be presenting a keynote address at World Biomaterials Congress in Korea! She will present her keynote titled “Biomimetic Scaffolds for Vaginal Tissue Engineering” during the “Biomaterials for Maternal-Fetal Interface” session from May 28, 2024, from 16:30 – 18:00 in room 314 …

In a remarkable display of innovation, Tista Mandal, Kristina Dalton, and Abir Hamdaoui showcased their senior design project, “CerVos: A Cervical Insufficiency Diagnostic Device to Prevent Preterm Labor,” at Washington University’s BME Day. Their groundbreaking device employs a spherical indentation technique coupled with a force-sensing load cell to assess cervical stiffness, offering a novel approach to diagnosing cervical insufficiency. Their aspirations to refine and commercialize the CerVos device underscore their commitment to advancing women’s health and medical technology, marking a significant milestone in the field of biomedical engineering …

A momentous achievement for Emily Sheehan as she successfully defended her master’s thesis, marking the culmination of her dedicated efforts in academia. With determination and perseverance, Emily showcased her expertise and scholarly prowess, impressing the panel with her insightful research. Our lab extends its heartfelt congratulations to Emily Sheehan on this significant milestone and wishes her continued success in her future endeavors …

A recent research paper titled “Evaluation of gelatin bloom strength on gelatin methacryloyl hydrogel properties” sheds light on the crucial role of gelatin properties in GelMA hydrogels, widely used in tissue engineering applications. Authored by Dr. Samantha G. Zambuto, Samyuktha S. Kolluru, Eya Ferchichi, Hannah F. Rudewick, Daniella M. Fodera, Kristin M. Myers, Silviya P. Zustiak, and Dr. Michelle L. Oyen, the study investigates the impact of gelatin bloom strength on hydrogel mechanical properties. Results reveal that both bloom strength and GelMA weight percent influence stiffness and viscoelastic ratio, while bloom strength specifically affects diffusivity, permeability, and pore size. The research, showcasing a library of GelMA hydrogels with varying properties, further examines how bloom strength influences trophoblast spheroid morphology. These findings offer valuable insights for designing tissue engineered constructs with optimal properties …

A groundbreaking research paper titled “Beyond 2D: Novel biomaterial approaches for modeling the placenta” has been recently published by Dr. Samantha Zambuto, Dr. Adrienne Scott, and Dr. Michelle Oyen. The paper delves into the realm of three-dimensional biomaterial environments for placenta research, offering fresh insights into the complexities of this vital organ. Exploring advanced fabrication techniques such as microfluidic device fabrication and 3D bioprinting, the paper showcases the potential for in vitro, three-dimensional placenta research to address health disparities and sexual dimorphism. This is a significant step forward in understanding and modeling the placenta, opening new avenues for future research in women’s health and pregnancy-related disorders …

Elevating collaboration: A snapshot capturing the vibrant energy and knowledge exchange at the joint open house event hosted by CRepHS and CWHE. 🌐🔬Samantha Zambuto (right) and Julie Emmerich (left) proudly standing in front of our poster at the collaborative open house event hosted by CRepHS and CWHE.Adrienne Scott (right) engrossed in a dynamic conversation with Rowan Karvas (left).Samantha Zambuto (right) and Antonina Frolova (left) engrossed in a meaningful conversation. Date: December 6, 2023 St. Louis, MO – In a collaborative triumph, the Center for Reproductive Health Sciences (CRepHS) and the Center for Women’s Health Engineering (CWHE) joined forces to host an immensely successful open house event on December 5, 2023. Held at Washington University’s Medical Campus, the event drew more than 70 attendees from the McKelvey School of Engineering and the School of Medicine, creating a dynamic platform for networking and knowledge exchange. The open house showcased the collective enthusiasm …

In a recent interview with St. Louis Public Radio, Dr. Michelle Oyen, a leading bioengineer at Washington University, passionately addressed the critical gaps in women’s health research. Following First Lady Jill Biden’s unveiling of the nation’s first initiative for women’s health research, Dr. Oyen expressed cautious optimism, emphasizing the need to bridge the disparities in understanding both reproductive and nonreproductive aspects of women’s health …

Dr. Michelle Oyen (right) captivating the audience with her groundbreaking insights at the Royal Society of Medicine meeting, as she discusses digital twins in pregnancy. Seated on the left, Roger Highfield, absorbed in the wealth of knowledge being shared. Date: November 3, 2023 London, UK – In a captivating session at the Royal Society of Medicine meeting, Dr. Michelle Oyen took center stage to share her expertise on the groundbreaking concept of digital twins in pregnancy. Dr. Oyen, renowned for her work in biomechanics and women’s health, delved into the intricacies of digital twin modeling, shedding light on its applications in pregnancy research. Notably, her pioneering work includes modeling C-section scars, exemplifying the potential of digital twins to revolutionize our understanding of maternal health. The insightful discussion at the Royal Society of Medicine reaffirms Dr. Oyen’s position as a trailblazer in the field, pushing the boundaries of medical science and …

Dr. Michelle L. Oyen, the esteemed Director of the Center for Women’s Health Engineering at Washington University in St. Louis, has been honored with induction into the American Institute for Medical and Biological Engineering (AIMBE). The prestigious ceremony, held on March 25 in Arlington, VA, saw Dr. Oyen among 162 esteemed colleagues inducted into this distinguished group. Election to AIMBE’s is a rare honor, limited to the top 2% of medical and biological engineers in their respective fields …

In a pioneering endeavor, Dr. Samantha Zambuto, PhD is set to deliver a transformative seminar, “Engineering Biomimetic Materials for Female Reproductive and Gynecologic Health,” on January 26, 2024 at 2pm, in the FUNG Auditorium – PFBH. Focused on the historically understudied realms of female reproductive and gynecologic health, Dr. Zambuto will delve into the unique biomechanical environment of the female reproductive tract by utilizing gelatin methacryloyl (GelMA) hydrogels to mimic and, instruct, and define the cellular microenvironment. Through the synergistic techniques of tissue engineering, biomaterials science, biomechanics, and reproductive biology, her talk promises to unveil groundbreaking insights into pregnancy-related disorders and birth injuries. Dr. Zambuto’s use of GelMA hydrogels, biomimetic and bioactive, highlights the innovative approach to mimic and define the cellular microenvironment in the female reproductive tract. Don’t miss this exceptional opportunity to gain profound insights into the future of women’s health research! …

The Oyen Lab at Washington University introduces cutting-edge pregnancy phantoms, providing an unprecedented visual journey into the realm of maternal health research …

Samantha Zambuto, Leading the Way: Sharing Insights on Vaginal Tissue Engineering at BMES 2023 Date: October 19, 2023 Saint Louis, MO – The Oyen Lab’s journey to the Biomedical Engineering Society (BMES) 2023 Annual Meeting in Seattle was nothing short of a resounding success! With a dynamic presence and a slate of compelling presentations, they made a significant impact on the biomedical engineering community. Dr. Samantha Zambuto set the stage with her illuminating presentation on “Composite Elastin Nanofiber-Gelatin Methacryloyl Hydrogels for Vaginal Tissue Engineering.” Her groundbreaking research captured the attention of the audience, further solidifying the lab’s position at the forefront of innovative tissue engineering. Dr. Michelle L. Oyen enriched the event with her insightful contributions in the panel discussion. Her perspectives on the future of biomedical engineering inspired attendees, fostering discussions that will undoubtedly shape the direction of the field. Hannah Rudewick exhibited her dedication to pre-eclampsia research through …

Professor Michelle L. Oyen, renowned for her groundbreaking work in materials science and engineering, has reached another pinnacle in her illustrious career as she assumes the role of Professor of Obstetrics and Gynecology at Washington University in St. Louis. Dr. Oyen’s appointment marks a significant step forward in her journey to transform healthcare through interdisciplinary collaboration and groundbreaking research …

Samyuktha Kolluru’s appointment as Vice Chair of the Global Health Student Advisory underscores Washington University’s commitment to fostering student leadership and collaboration in the pursuit of global health equity and improved healthcare outcomes worldwide. Her dedication and vision are expected to play a significant role in shaping the future of global health initiatives at the university …

The Oyen Lab’s outreach event at Washington University, led by Dr. Adrienne Scott and Patrick Yang, provided Pattonville High School Biological Science students with an immersive and educational experience in placental science. Through engaging demonstrations and hands-on activities, the students gained a deeper appreciation for the vital research conducted at the lab and left inspired by the possibilities of scientific discovery …

Dr. Samantha Zambuto and Dr. Adrienne Scott, Postdoctoral Scholars from Washington University, left an indelible mark at the IFPA Conference in Rotorua, New Zealand, where they showcased their groundbreaking research in placental health …

Oyen Lab at Washington University has welcomed a cutting-edge Optical Coherence Tomography (OCT) microscope from Thor Labs, opening up new frontiers in biomedical imaging. Lab manager, Patrick Yang, and PhD graduate student, Samyuktha Kolluru, are leading the setup and training under the expert guidance of Martin Thunert from Thor Labs …

Samantha Zambuto and Adrienne Scott, Postdoctoral Scholars from Washington University, are set to present their pioneering research in placental science and technology integration at the IFPA Conference in Rotorua, New Zealand, from September 5 to September 8, 2023. Samantha focuses on the properties of hydrogels and their role in modeling pregnancy, while Adrienne employs cutting-edge technology and AI to delve into placental development and early fetal problem identification …

Date: 4 October 2023 Seattle, WA – The Oyen Lab is gearing up for the Biomedical Engineering Society (BMES) 2023 Annual Meeting, set to take place at the Seattle Convention Center from October 11 to October 14. The lab members have an exciting lineup of presentations and discussions in store. 🔬Dr. Samantha Zambuto will be in the spotlight on October 12, from 12:45 pm to 1:00 pm PDT. She will be presenting her research on “Composite Elastin Nanofiber-Gelatin Methacryloyl Hydrogels for Vaginal Tissue Engineering.” Dr. Zambuto will also be presenting her future research goals at the 2023 Meet the Faculty program on October 11, from 3:00 pm to 5:00 pm PDT in Exhibit Hall 2. Her poster number is 89-CM. Don’t miss this opportunity to delve into cutting-edge advancements in tissue engineering. 🌟Dr. Michelle L. Oyen, the lab’s visionary leader, will be participating in a panel discussion on October 12, …

Samyuktha Kolluru (Left) and Erica Marquez (Right) working with the microindenter Precision at the Microscale In the realm of microscale mechanics and materials research, precision is our compass, and innovation is our goal. Welcome to our research laboratory, where we introduce you to the transformative capabilities of the Instron Microindenter—a foundational instrument that propels our microscale mechanical investigations, offering the precision and insights essential to advancing our team’s collective knowledge. The microindenter is more than a piece of equipment; it’s an enabler of groundbreaking discoveries and collaborative excellence. Here’s how it empowers our team’s research endeavors: Microscale Precision: Our team relies on the microindenter’s unparalleled precision to probe the mechanical intricacies of materials at the microscale. It empowers us to meticulously characterize properties like hardness, stiffness, and elasticity with unmatched accuracy. Versatile Research Tool: Whether we’re examining thin films, microfabricated structures, biomaterials, or coatings, the microindenter seamlessly adapts to our …

Welcome to a world of unprecedented vision and insight. Discover the remarkable capabilities of the Optical Coherence Tomography (OCT) Microscope, a revolutionary instrument that empowers one to explore the hidden intricacies of biological tissues, materials, and structures. Gateway to Clarity: Micron-Level Precision: OCT is renowned for its exceptional imaging capabilities, allowing one to capture cross-sectional images with incredible detail. Peer beneath the surface, visualize tissue layers, and unveil the microstructures. Adaptability Across Domains: OCT seamlessly adapts to a wide range of applications, from diagnosing medical conditions to assessing material integrity. Efficiency Redefined: Time is of the essence in one’s work. The OCT Microscope enhances one’s workflow with its non-invasive, label-free imaging capabilities. Real-time imaging empowers one to make swift observations and gather critical data efficiently. Multi-Modal Insights: Advanced OCT systems offer multi-modal capabilities, integrating other imaging techniques such as fluorescence, confocal microscopy, and angiography. This fusion of imaging modalities allows …

In the world of research, innovation and precision are paramount. Welcome to our laboratory, where we introduce you to the exceptional capabilities of the Dremel DigiLab 3D Printer. Your Creative Playground: Precision Engineering: Experience the power of precision with this 3D printer. It transforms your digital designs into physical prototypes with exceptional accuracy, allowing you to explore intricate details and test your hypotheses with confidence. Endless Exploration: Whether you’re delving into the realms of material science, biology, or engineering, the Dremel Digilab 3D Printer adapts seamlessly to your research needs. It’s a versatile tool that enables you to prototype a wide range of objects and components. User-Friendly Design: Modern 3D printing technology ensures an effortless experience. The Dremel Digilab 3D Printer features an intuitive interface, user-friendly software, and convenient controls, allowing you to focus on your research goals without unnecessary complexity. Diverse Materials: Explore a world of possibilities with a …

In the realm of cutting-edge research, precision and innovation reign supreme. Welcome to our laboratory, where we introduce you to the groundbreaking capabilities of the MECC Nanon Electrospinner—an instrumental tool poised to revolutionize the field of nanofiber research. Empowering Nanoscale Exploration: Nanoscale Precision: Immerse yourself in the world of nanotechnology with unmatched precision. The Electrospinner transforms polymer solutions into ultrafine fibers with meticulous accuracy, enabling you to explore the most intricate nanofiber structures and materials with confidence. Endless Possibilities: Whether you’re exploring tissue engineering, advanced materials, or filtration technologies, the Electrospinner seamlessly adapts to your research needs. It’s a versatile tool that empowers you to create nanofiber scaffolds, membranes, and novel nanomaterials. User-Friendly Design: The Electrospinner features an intuitive interface, user-friendly software, and advanced safety measures, ensuring a streamlined and productive research experience. Material Freedom: Dive into a world of material possibilities with a wide range of compatible polymer solutions …

Welcome to our research laboratory, where we introduce you to the transformative capabilities of the Nanoindenter—a cornerstone instrument that fuels our nanomechanical investigations, delivering precision and insights that propel our team’s collective knowledge forward. Nanomechanical Exploration: Nanoscale Precision: Our team relies on the Nanoindenter’s extraordinary precision to explore the mechanical intricacies of materials at the nanoscale. It enables us to delve deep into hardness, stiffness, and elasticity characterization with meticulous accuracy. Versatile Research Platform: Whether we’re delving into thin films, biomaterials, advanced coatings, or composite materials, the Nanoindenter seamlessly adapts to our diverse research needs. It’s a versatile instrument that accommodates a wide range of mechanical tests and experiments, fostering interdisciplinary collaboration within our team. User-Friendly Interface: Modern Nanoindenters prioritize user-friendliness, enhancing the collective productivity of our team. The Nanoindenter’s intuitive interface, user-friendly software, and advanced automation features ensure that we can conduct experiments efficiently, collectively driving our research goals …

Elevating Your Research with the KEYENCE Fluorescence Microscope As a passionate researcher in our cutting-edge laboratory, you understand the pivotal role of precision tools in your work. That’s why we’re thrilled to introduce the KEYENCE Fluorescence Microscope to our facility, empowering you to unlock new frontiers in your scientific endeavors. Key Features: High Clarity: Capture high-resolution images that uncover intricate details at the cellular and subcellular levels, providing invaluable insights for research and analysis. Versatile Imaging Modes: Choose from various imaging modes, including brightfield, fluorescence, phase contrast, and DIC, to adapt to a wide range of research applications. User-Friendly Design: With an intuitive interface and straightforward controls, the KEYENCE Fluorescence Microscope ensures effortless operation for researchers of all skill levels. Broad Applications: Whether you’re exploring life sciences, material research, or industrial analysis, this microscope excels in diverse fields such as cell biology, live cell imaging, and neuroscience. Reliable Long-Term Performance: …

The Fourier-Transform Infrared Spectroscopy (FTIR) allows one to uncover the hidden secrets of substances, analyze materials, and gain insights like never before. A Gateway to Molecular Understanding: FTIR is not merely an instrument; it’s the key to unlocking the secrets of molecular structures. Here’s how FTIR empowers one’s research and fuels their scientific curiosity: Molecular Fingerprints: FTIR spectroscopy unveils the unique “fingerprint” of molecules by measuring their interaction with infrared radiation. It provides a non-destructive means to identify, characterize, and quantify a myriad of compounds, shedding light on their composition, structure, and chemical bonds. Versatility Unleashed: Whether one is probing the composition of polymers, investigating pharmaceutical formulations, analyzing food constituents, or exploring forensic evidence, FTIR adapts to your diverse analytical needs. Its versatility makes it an indispensable tool across various scientific disciplines. Researcher-Centric Design: Modern FTIR spectrometers feature intuitive user interfaces, automation capabilities, and user-friendly software, ensuring an efficient and …